ULTRA HGH Muscle Building and Tissue Repair Tap into your inner power with MF PLUS Ultra HGH

Muscle Building and Tissue Repair

Tap into your inner power with MF PLUS Ultra HGH, which activates your body’s potential for enhanced muscle building, musculoskeletal health, tissue repair and recovery, body composition regulation, and growth stimulation.

• 191 Amino Acid Sequence
• 15-25kDa Molecular Weight
• 100% Purity

HGH is a human growth hormone synthesized and secreted by somatotrophs cells in the anterior pituitary. It plays an essential role in controlling several complex physiologic processes, including growth and metabolism. In addition, HGH is vital for normal brain function. HGH level peaks at about age 20 and steadily declines as we age.

An individual with growth hormone deficiency often experiences symptoms as follows;

• Metabolic abnormalities.
• Anxiety and depression.
• Decreased interest in sexual activity.
• Fatigue and less stamina.
• Low bone mineral density (osteopenia).

Overall benefits of MF Plus Ultra HGH

• Regulates body fluids.
• Enhances injury recovery and muscle tissue repair.
• Increases muscle mass.
• Supports bone regeneration.
• Improves growth hormone serum level.
• Promotes regulation of blood sugar and fat metabolism.

HGH exerts its effects both directly and indirectly:

• Direct effects result from growth hormone binding its receptor on target cells to stimulate a response.
• Indirect effects are mediated primarily by an insulin-like growth factor-I (IGF–1) secreted from the liver and other tissues in response to growth hormone. Most of the growth-promoting effects of growth hormone are due to IGF-1 acting on its target cells.

HGH signalling is required for promoting longitudinal body growth, stem cell activation, differentiation, and survival and for regulation of metabolism. HGH induces growth in nearly every tissue and organ in the body and stimulates linear growth and cartilaginous growth of long bones. In children with short stature, HGH increases both the number and size of muscle cells. It also promotes the development of internal organs, and it also increases red cell mass.

By promoting nitrogen retention, HGH increases cellular protein synthesis. HGH also retains potassium and phosphorus in the serum, resulting from cell growth.

HGH stimulates the synthesis of chondroitin sulphate and collagen, in end-stage renal disease, HGH exhibit the ability to improve several nutritional parameters, such as increases in serum insulin-like growth factor-1 (IGF-1), serum albumin, and transferrin, as well as a reduction in blood urea nitrogen.

The upregulation of IGF-1 causes the metabolic effects of HGH. Generally, HGH leads cells to enter an anabolic protein state with increased amino acid uptake, protein synthesis, and decreased catabolism of proteins.

HGH stimulates lipolysis via activation of the hormone-sensitive lipase in the adipose tissue, thereby increasing circulating levels of free fatty acids and triglycerides in the plasma. It also leads to reducing fat stores and decreased serum levels of low-density lipoprotein (LDL) cholesterol. In contrast to the effects seen in the adipose tissue, HGH promotes cellular uptake of free fatty acids in skeletal muscle by increasing lipoprotein lipase activity.

HGH may cause hyperinsulinism following beta-cell compensation for insulin resistance; however, there is some evidence that growth hormone directly promotes beta-cell proliferation and glucose-stimulated insulin secretion.

Mechanism of action:

In conditions of growth failure, growth hormone deficiency, low body mass, and malnutrition, HGH treatment acts to mimic and restore the actions of endogenous growth hormone of stimulating linear bone growth, increasing bone mass, increasing muscle, reducing fat mass, and regulating blood glucose and lipid levels.

HGH mediates its effects directly by HGH and indirectly by IGF-1. HGH binds to the human growth hormone receptor (GHR), a dimeric receptor expressed in target cells in the liver and cartilage, resulting in forming a GH-(GHR)2 complex. Upon HGH binding, the GHR is phosphorylated by JAK2 and recruit the signal transducer activator of the transcription (STAT) pathway. Transcription factors such as STAT1, STAT3, and STAT5 are translocated into the nucleus to stimulate target gene transcription.

At the epiphysis or growth plate, growth hormone increases linear growth by promoting differentiation of prechondrocytes and expansion of osteoblasts. Growth hormone binding to its receptor in the liver and cartilage encourages the production of IGF-1, which acts on type 1 IGF receptors to stimulate linear growth. In the liver, activated growth hormone receptor signalling leads to increased production of IGF binding protein-3 (IGFBP-3) and acid-labile subunit (ALS), which bind to IGF-1 in a ternary complex to increase its half-life.